1,1-dioxopenicillanoyl oxymethyl d-6-(alpha-(methyleneamino) phenylacetamido)-penicillanate and its salt, preparation thereof and remedy for bacterial infection therefrom

Abstract

NEW MATERIAL: Compounds given by formula I. USE: Remedy for bacterial infections. PROCESS: An iodomethyl derivative of sulbactam, 3,3-dimethyl-7-oxo-4-thia-1- azabicyclo(3,2,0)heptane-2-carboxylic acid, 4,4-dioxide[2S(2α.5α)] is reacted with methanepicilin,6-[D(-)-α-(methylamino)phenylacetamido]penicillanic acid (salt) of formula III (wherein M is H, ammonium or an alkali metal) in the presence of a solvent (preferably DMF) preferably at -5-5°C for 3-24 hr. COPYRIGHT: (C)1991,JPO

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